Figure 10From: Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemiaInhibiting effect of siRNA and SnPP on HO-1 in neonatal hyperbilirubinemia rats modes. A. siRNA-4 and SnPP were injected intraperitoneally into 7-day-old rats respectively, and serum total bilirubin levels decreased significantly in both group. Compared with SnPP, siRNA-4 was more effective at reducing indirect bilirubin. * P < 0.05, compared with NC group; # P < 0.05, compared with ALA+NC-siRNA group. B. The expression of rHO-1 in liver was analyzed by Real-Time PCR. The level of HO-1 expression in siRNA-4 treatment group was significantly lower than that in NC-siRNA group. However, the HO-1 level increased significantly in SnPP group. * P < 0.05 compared with NC group. Data represent the results from one of two independent experiments. Each group contained 6–8 mice.Back to article page