Table 1 Alternative uPAR splicing identified in the RACE analyses
Variant | 5'Donor site | 3'Acceptor site | Implication |
|---|---|---|---|
E3 deletion | GCGCTTGTGGGAAG | GCCGGGCTGTCAC | In frame deletion, removal of 48 residues |
E4+5 deletion | CCAGGGCAACTCTG | TCCTGGAGCTTGA | In frame deletion, removal of 100 residues, valine insertion |
E5 deletion | AGGTGAAGAAG | TCCTGGAGCTTGA | In frame deletion, removal of 46 residues, valine insertion |
E6 deletion (with E7) | CAACGAGGGCCCAA | AACCGAAAAACC | In frame deletion, removal of 50 residues, lysine insertion |
E6 deletion (with E7b) | CAACGAGGGCCCAA | AACGCTCACTCTGG | In frame deletion, removal of 50 residues, lysine insertion |
E5+6 deletion (with E7) | AGGTGAAGAAG | AACCGAAAAACC | In frame deletion, removal of 94 residues |
E3+4+5 deletion | GCGCTTGTGGGAAG | TCCTGGAGCTTGA | In frame deletion, removal of 148 residues, valine insertion |