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Figure 3 | BMC Molecular Biology

Figure 3

From: Expression of HNF4alpha in the human and rat choroid plexus – Implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier

Figure 3

HNF4α binding to promoters of ABCB4 and ABCC1. Electrophoretic mobility shift assays with 2,5 μg Caco-2 cell nuclear extract and oligonucleotides corresponding to the A-site of the HNF1α promoter (HNF1pro) and to putative HNF4α binding-sites within human (A), rat (B) and mouse (C) ABCB4 and ABCC1 as 32P labeled probe. In supershift assays an antibody directed against HNF4α (+) was added. For oligonucleotide sequence information see Table 2 and 3.

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