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Figure 2 | BMC Molecular Biology

Figure 2

From: Cooperation between NRF-2 and YY-1 transcription factors is essential for triggering the expression of the PREPL-C2ORF34 bidirectional gene pair

Figure 2

Determination of the size and sequence of the intergenic region between human C2ORF34 and PREPL genes. A) The first few exons of C2ORF34 (black boxes) and PREPL (grey boxes), the introns, and the shared intergenic segment (middle white bar) are shown. Bent arrows represent the gene directions and transcriptional start sites (TSSs) identified by 5'-RACE. The shortest intergenic distance between the two genes is calculated to be 405 bp and numbered (from -1 to -405) from the telomeric (tel) to the centromeric (cen) end. B) The 5'-RACE products, which were sequenced from the shared intergenic region to the direction of downstream gene transcription, revealed multiple TSSs (marked with an asterisk) including two for C2ORF34 and three for PREPL. C) The bent arrows and the bold C and G nucleotides denote the different TSSs for C2ORF34 and PREPL, respectively. The 405-bp intergenic region is boxed.

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BMC Molecular Biology

ISSN: 1471-2199

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