Table 2 Characteristics of human SHBG alternative first exons.
Exon 1A | Exon 1B | Exon 1C | Exon 1D TSS1/TSS2 | Exon 1D | |
|---|---|---|---|---|---|
Genomic position Chr 17 | 7472100–7472194 | 7471721–7471824 | 7471362–7471468 | 74758017/070–74758154 | 7457930–7458004 |
Strand | Positive | Positive | Positive | Positive | Positive |
Length (nt) | 95 | 104 | 107 | 137/85 | 75 |
Open reading frame | No (1uATG) | No | No | No (2/1uATG) | No (1uATG) |
2ry structure (MFOLD) kcal/mol | -40.3 | -64.4 | -50.6 | -45.3/-20.8 | -35.8 |
5' splice site | TGG/gtaagc | CTG/gtaagt | TGG/gtacgg | AAG/gtatgt | GGG/gtgagt |
Exonic splicing enhancers | SF2/ASF (2) SC35 (2) SRp40 | SF2/ASF (5) SC35 (3) SRp55 | SRp20 SRp40 | SF2/ASF (2)/(0) SC35 (1)/(1) SRp40 (1)/(1) SRp55 (1)/(1) | SF2/ASF SRp40 (2) SRp55 |