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Figure 1 | BMC Molecular Biology

Figure 1

From: Improved long-term expression from helper virus-free HSV-1 vectors packaged using combinations of mutated HSV-1 proteins that include the UL13 protein kinase and specific components of the VP16 transcriptional complex

Figure 1

X-gal positive striatal cells from rats that received microinjections of pNFHlac packaged using specific combinations of mutated HSV-1 proteins. The rats were sacrificed at 4 days, 2 months, or 3 months after gene transfer. A-C. pNFHlac/ul13g; 4 days after gene transfer (A), 2 months (B), and 3 months (C). D-F. pNFHlac/VP16in14, gene12; 4 days (D), 2 months (E), and 3 months (F). G-I. pNFHlac/Δul46&47, ul13g; 4 days (G), 2 months (H), and 3 months (I). J-L. pNFHlac/VP16in14, gene12, ul13g; 4 days (J), 2 months (K), and 3 months (L). These high power views show X-gal positive cell bodies and proximal processes. Scale bar: 25 μm.

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