Figure 5
From: The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs
STAR/GSG domain protein alignment. (A) Diagram representing the structural and functional region of the STAR/GSG domain containing proteins. (B) The STAR/GSG domain of mouse SLM-2, human SAM68, mouse QKI, C. elegans GLD-1 and human SF-1 were aligned using ClustalW. Secondary structure, beta sheets and alpha helices, are shown on top of the sequences and region NK/QUA1, the KH domain and region CK/QUA2 are shown beneath the sequences. The critical loop between helices alpha 1 and alpha 2 with the GXXG sequence is also shown. (a) Based on [6] the RNA bases UACUAAC that contact with the specific SF-1 residues are numbered as follow U1A2C3U4A5A6C7. (b) Arginine 160 makes contact with U4 and A6. (c) Valine 183 makes contact with A6 and C7.