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Table 4 DSB initiation at hotspot Kcnq1 is unaffected by epigenetic imprinting.

From: Parental origin of chromosomes influences crossover activity within the Kcnq1 transcriptionally imprinted domain of Mus musculus

 

Genotypes

 

Initiating Chromosome

Animals

SNP1

(143,017,421)

SNP2

(143,018,553)

SNP3

(143,019,622)

Count

Parental

Strain

B6×CAST

B

C

C

10

Maternal

21

B6

 

C

C

B

11

   
 

B

B

C

4

Paternal

6

CAST

 

C

B

B

2

   

CAST×B6

B

B

C

3

Maternal

5

CAST

 

C

B

B

2

   
 

B

C

C

8

Paternal

17

B6

 

C

C

B

9

   
  1. Examining 49 recombinant offspring at the Kcnq1 hotspot showed DSBs preferentially occurs on the B6 chromosome, regardless of the chromosome's parental origin. SNP position indicated in parentheses (base pairs – Build 36).
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BMC Molecular Biology

ISSN: 1471-2199

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