Parental origin of chromosomes influences crossover activity within the Kcnq1 transcriptionally imprinted domain of Mus musculus

Table 2 Epigenetic imprinting influences recombination activity within the Kcnq1 imprinted domain.

	Sex-Averaged Recombination Activity		Number of Crossovers in B6♀ × CAST♂ Parental Cross			Number of Crossovers in CAST♀ × B6♂ Parental Cross			Sex-averaged CxB:BxC Ratio
Hotspot	cM	cM/Mb	Male	Female	Total	Male	Female	Total	Ratio		P_FET Value
Th	0.40	33.7	9	2	11	11	2	13	1.2	0.92	0.83	0.63
Kcnq1	0.73	308	25	2	27	19	3	22	0.81		0.47
Cdkn1c	0.12	71.2	0	2	2	3	2	5	2.5	3.3	0.45	0.005
Slc22a18	0.22	367	2	0	2	9	2	11	5.5		0.02
Nap1l4	0.15	243	3	0	3	7	0	7	2.3		0.34

Hotspots Slc22a18 and its flanking hotspots, Cdkn1c and Nap1l4, clustered within 100 kb and showed a regionally significant increase in crossover activity in F1 animals from CAST♀ × B6♂ parents. Both sexes showed higher number of recombinant in the CAST♀ × B6♂ parental cross within the 100 kb cluster with a C×B:B×C ratio of 3.8 for males and 2.5 for females.

ISSN: 1471-2199