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Figure 2 | BMC Molecular Biology

Figure 2

From: TCF/β-catenin plays an important role in HCCR-1 oncogene expression

Figure 2

Mutational analysis of the HCCR-1 promoter. The diagrams depict locations of the predicted transcriptional elements in the HCCR-1 promoter. When mutated, the diagrams are indicated by a cross. "Tcf" and "My" indicate the consensus sequences for the TCF and C-Myb elements, respectively. Each luciferase reporter construct was co-transfected in K562 cells with pRL-CMV. The horizontal axis shows the ratio of luciferase (LUC) to renilla (REN) activity normalized by LUC/REN (= 100%) displayed by cells co-transfected with pRL-CMV and pGL3-control (n > 4 per construct).

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