Figure 6

Progression of cultured mES cells towards hepatocyte-lineages. The figure shows the progression of mES cells in NDESM and HIM cultures along the hepatocyte-lineages. [AFP = α-fetoprotein, HNF-1b, HNF-3b, HNF-3a, HNF-4a, HNF-6 = hepatocyte nuclear factor-1β, -3β, -3α, -4α and 6, respectively; C/EBP-a, C/EBP-b = CCAAT-enhancer binding protein-α, -β, respectively; TAT = tyrosine aminotransferase, Cyp3a = cytochrome P450-3a, Pepck = phosphoenolpyruvate carboxykinase, TDO = tryptophan 2,3-dioxygenase, (low) = the expression level is low].