Figure 1

Summary of alternatively spliced transcripts of Mus musculus Rad51d. (A) The ten exons of Rad51d are shown as numbered boxes drawn relative to base pair length with both the full-length transcript (upper panel) and each alternatively spliced transcript shown (lower panel). Shaded areas designate partial intron retention (+int3) or partial exon exclusion (Δ7b). (B) Predicted translation products of the RAD51D isoforms are illustrated. Black and yellow boxes indicate the location of Walker Motifs A and B respectively. A core helix-hairpin-helix-GP rich domain (blue) and linker region (red) are also indicated. Amino acids introduced by splicing induced frameshift in the transcripts of RAD51DΔ8, RAD51DΔ3, and RAD51DΔ3,7b are colored green with the corresponding novel sequence following. Asterisks represent sites of premature termination codons.