Table 2 R. microplus homologues with high conservation (≥ 80% identity) to 13 D. melanogaster proteins following RNAi knockdown in vitro (11 associated with significant cell viability z scores at >3 and 2 controls at<3)
R. microplus BmiGI2 Reference* | D. melanogaster description | D. melanogaster cell culture RNAi cell growth and viability Z-scores§ | |||
|---|---|---|---|---|---|
| Â | Functional group assignment | Gene Symbol (Name) | InterPro Domains ID (Name) | Kc167 | S2R+ |
TC5762 | Ribosome and protein synthesis | sop (string of perls) | IPR000851 (Ribosomal Protein S5) | 2.9¶ | 2.9¶ |
TC5823 | Energy and metabolism | ATPsyn-(beta) (ATP synthase-(beta)) | IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide binding) | 5.0 | 2.0 |
TC6116 | DNA binding | His3.3A (Histone H3.3A) | IPR000164 (Histone H3) | 2.4 | 3.9 |
TC6372 | Proteasome and ubiquitin | Ubi-p63E (Ubiquitin-63E) | IPR000626 (Ubiquitin) | 7.7 | 5.9 |
TC9037 | Ribosome and protein synthesis | RpL11-PA (Ribosomal protein L11) | IPR002132 (Ribosomal Protein S5) | 3.2 | 3.0 |
TC9417 | DNA binding± | CG2807 | IPR000357 (Heat) | 4.3 | 6.1 |
TC9852 | Proteasome and ubiquitin | Pros26.4 (Proteasome 26S subunit subunit 4 ATPase) | IPR003593 (AAA ATPase) | 4.8§ | 2.8 |
TC10417 | Proteasome and ubiquitin | Rpt1 | IPR003593 (AAA ATPase) | 4.5§ | 2.9 |
TC12182 | DNA binding | His3.3A (Histone H3.3A) | IPR000164 (Histone H3) | 2.4 | 3.9 |
TC12306 | Ribosome and protein synthesis | RpL8 (Ribosomal protein L8) | IPR002171 (Ribosomal Protein L2) | 3.2 | 3.4 |
TC12372 | Ribosome and protein synthesis | RpL10Ab (Ribosomal protein L10Ab) | IPR002143 (Ribosomal Protein L1) | 2.3 | 3.7 |
TC12393 | Ribosome and protein synthesis | RpS13 (Ribosomal protein S13) | IPR000589 (Ribosomal Protein S15) | 3.4§ | 1.0 |
TC13930 | Proteasome and ubiquitin | Tbp-1 (Tat-binding protein-1) | IPR003593 (AAA ATPase) | 0¶ | 0¶ |