Figure 1
From: A functional type I topoisomerase from Pseudomonas aeruginosa
Sequence alignment of P. aeruginosa topoisomerase I with homologous topoisomerases IB. The amino acid sequences from Entomopoxvirus (MSV130), Bovine Papular Stomatitis virus (BPSVgORF062), Orf virus (ORFVgORF062), Vaccinia virus (H6R, Vaccinia topoisomerase type IB), Fowl Pox virus (FPV143) and D. radiodurans topoisomerase IB (DR_0690) are aligned with the P. aeruginosa topoisomerase I (PA2G_01347). Sequence gaps are indicated by dashes. The residues in blue and red correspond to identical and conserved residues, respectively. The asterisks in black identify the conserved catalytic residues. The N-and C-terminal domains are demarcated by arrows.